The configuration, composition and aims of the bioprocesses make them unique between each other, even if the target molecule and source of biosynthesis are the same. Many authors categorise bioprocess in two main parts, upstream bioprocess and downstream bioprocess. The upstream bioprocess focuses in how the target molecule is produced or synthesised while the downstream bioprocess focuses on how this molecule is going to be recovered or purified. If we centre our attention on downstream bioprocess integration, we are talking about how to the operation units that conform the downstream bioprocess interact between them in order to have a holistic understanding on how the molecule is being retrieved. After the interactions between the operation units are well known and studied, the integration of the bioprocess can be done by substituting two or more unit operations by one unit capable of achieving the same process aim without losing yield or molecule denaturalisation.
At our research team, we use the bioprocess integration to augment the taxane yields using novel methodologies. These strategies occurs mainly in the extraction steps where we are intensifying the bioprocess making two or more processes in one this single step to recover more taxanes.
Figure taken from:
Kiss, A.A., Grievink, J. and Rito-Palomares, M. (2015), A systems engineering perspective on process integration in industrial biotechnology. J. Chem. Technol. Biotechnol., 90: 349-355. https://doi.org/10.1002/jctb.4584