Our group is working on applying synthetic biology tools to engineer microbial cell factories to produce high value a bulk products such as biofuels, biopolymers, pharmaceuticals. We are mainly focusing on isoprenoids (e.g. anti-cancer drug Taxol), chiral amino-alcohols and venturing in marine natural products using microbial hosts such as S. cerevisiae, Y. lipolytica, E. coli, C. glutamicum and P. aeruginosa.
We use different novel in house genome engineering tools which allow to multiplex to rapidly build and optimise stable synthetic pathways. We aim to combine the tools of proteomics, transcriptomics, metabolomics, kinetic modelling, next generation sequencing and microscale automated instrumentation to rapidly detect the bottlenecks and optimise the pathway using engineering principles.